Autologous skin transplantation for widespread cutaneous necrosis in secondary antiphospholipid syndrome.

LESSON OF THE MONTH Autologous skin transplantation for widespread cutaneous necrosis in secondary antiphospholipid syndrome

Cutaneous involvement in primary and secondary antiphospholipid syndrome often is a therapeutical dilemma. Here we describe a case of widespread cutaneous necrosis due to thrombosis of the microvasculature, and cutaneous vasculitis in secondary antiphospholipid syndrome in a patient with systemic lupus erythematosus. Autologous skin transplantation was able to cover the skin defects but was onl...

Widespread cutaneous necrosis as the first clinical manifestation of secondary antiphospholipid syndrome.

Antiphospholipid syndrome (APS) is an acquired prothrombotic state characterized by recurrent thromboses, pregnancy loss, thrombocytopenia, and the presence of antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant and/or anti2-glycoprotein antibody. The original clinical and laboratory criteria for APS, called the Sapporo criteria, were first published in 1999. These were...

The antiphospholipid antibody syndrome: diagnosis, skin manifestations and current therapy.

Antiphospholipid antibody syndrome is characterized by venous and/or arterial thrombosis and/or pregnancy morbidity associated with antiphospholipid antibodies (aPL), such as anticardiolipin antibodies, anti beta 2 glycoprotein I antibodies and positive lupus anticoagulant test. This syndrome may potentially affects any organ system including the skin. Livedo reticularis is the most frequently ...

Metastatic melanoma of the tongue: a rare case.

Only 23 cases of extensive cutaneous necrosis linked to APS have been reported in the literature. Most of the patients have been young women and the underlying diseases included SLE (9 cases), lupus-like disease (1 case), urinary tract infection (2 cases), acquired immunodeficiency syndrome (1 case), rheumatoid arthritis (1 case), mycosis fungoides (1 case), and mixed connective tissue disease ...

Malignant Melanoma and Melanocytic Nevi Fibrohistocytic Lesions of the Skin Publications Retiform purpura and digital gangrene secondary to antiphospholipid syndrome successfully treated with sildenafil